Home › NEET PG preparation › Biochemistry
Biochemistry carries fewer questions than most subjects, but they are two-step, tied to diseases and easy to lose once the pathways fade after 1st year. Below are the teachers, books and question habits toppers and students credit for it, the topics that keep repeating, and how to keep it sharp until the exam.
For the 180-question format, Careers360 estimates about 4–6 Biochemistry questions and ReflexPrep 6–9 (August 2026), a band of roughly 4 to 9 built from recalled papers. PrepLadder's review of the 2025 paper noted relatively few Biochemistry questions, yet DBMCI's analysis of the same paper found students rating it among the hardest.
Few, but not simple. Careers360's write-up of Marrow's 2025 analysis found “More of two step questions” and clinical, application-type questions built on previous-year topics. PrepLadder's 2026 guidance notes that Biochemistry often sat inside questions combining several subjects. In a two-step question you first identify the disease from the case, then answer about the enzyme or pathway behind it.
Pictures appear as well. PrepLadder's Biochemistry image set uses molecular structures, pathway diagrams such as fructose metabolism and the electron transport chain, Benedict's and Fehling's tests, and clinical photographs: the cherry-red spot of Tay-Sachs disease, angiokeratomas in Fabry disease, the cataract of galactosaemia, and Gaucher cells.
Medioks' routine for the year: attend lectures and practicals, read the matching chapter, draw pathways, keep concise notes and revise weekly, then practise previous university questions and link each topic to a disease. It adds that the subject gets easier when studied consistently through the year. Vasudevan or Satyanarayana covers the university exam, with Harper or Lippincott for concepts that need more depth.
Second year brings Pathology, which revisits storage diseases, haemoglobin and genetics from the disease side. Revise each from both directions in the same week. Keep 20–30 minutes on most days for the pre-clinical subjects, as Careers360 suggests, plus a short weekly set of Biochemistry MCQs. Dr Naisargi (AIR 19, NEET PG 2025) made a point of fortifying the basics from second year itself.
Inborn errors, storage disorders and vitamin deficiencies come back as Paediatrics and Medicine cases. When a case points to a metabolic disease, ask which enzyme and which pathway step are involved; that is the second step of a two-step question. Start Grand Tests, and log every Biochemistry error in one notebook; the 2026 AIR 1, Dr Monish, kept exactly such a record.
One pathway and a short question set fits a break on duty. Month one of DigiNerve's intern plan is for the pre-clinical subjects, and DBMCI's internship advice is a daily set of PYQs at minimum. Work from rapid-revision notes rather than the textbook, and hold the full Biochemistry revision for the final weeks before the exam.
PrepLadder's Method A starts with the first-year subjects, while Oncourse's 2026 guide warns against opening the whole preparation with an easier subject such as Biochemistry. A middle path fits both views: one pass early in the year, then a dedicated revision near the end, because PrepLadder treats Biochemistry as a high-volatility subject to emphasise in the final days.
For fitting Biochemistry around Anatomy and Physiology in the first year, see the 1st-year MBBS guide.
Student recommendations for Biochemistry have pointed to Dr Rebecca James, Marrow's teacher for the subject, since at least 2020. Dr Shagun Batra (AIR 1, NEET PG 2022) credited her in a Careers360 interview, a 2020 student guide recommended her, and Careers360's 2026 book list names her Self-Assessment and Review of Biochemistry. CollegeDekho's 2025 article on preparation mistakes offers Rebecca James or DM Vasudevan as the book to use.
A first-year student asked for Biochemistry options under a 2025 platform-choice video, and 2025–26 comments show several routes. A 2nd-year student's 2026 line-up uses Dr Rajesh Jambhulkar of PW MedEd, who, according to PW, reaches over 300,000 students through his YouTube channel. A Marrow user under Dr Sukriti Kaushik's resources video took Biochemistry from Marrow's rapid revision, and an intern who builds flashcard decks from coaching notes based his 2025 Biochemistry deck on the same Rapid Revision notes.
“she made Biochemistry very easy to understand”
Revised Biochemistry from BTR and Marrow's rapid revision, and backed both with lots of MCQs.
Listed Dr Jambhulkar for Biochemistry beside Dr Ashwani Kumar for Anatomy and Dr Soumen Manna for Physiology.
| Platform | Biochemistry teacher | Course |
|---|---|---|
| Marrow | Dr Rebecca James | Edition 8.5 “Clinical Edge” |
| PrepLadder | Dr C Shanmugapriya | Version XI |
| Cerebellum | Dr Ankur Jain and Dr Smily Pruthi | Mission 4.0 |
| DBMCI One | Dr Amit Jain | Live ’27 |
| DocTutorials | Dr Priyansh Jain | Edition 6 |
| PW MedEd | Dr Rajesh Jambhulkar | One Plan |
Rosters as listed on each platform's own 2026 course pages (read 2 Oct 2026). Teachers do change between editions, so check the course page before you buy.
In the resource lists students shared in 2025–26, Biochemistry often comes from one rapid-revision source plus plenty of questions, with full lectures kept for topics that will not click. A 2019 intern's guide put the logic plainly: revising one source three times beats reading three sources once. The platforms page compares what each course offers.
The Biochemistry areas that recur most in PYQs, according to PrepLadder's August 2026 analysis, are inborn errors, enzyme deficiencies, carbohydrate and lipid metabolism, molecular biology and nutrition, so start with those. Its Biochemistry topic guide advises staying with conceptual, frequently asked topics and letting rare ones go, since a rare question is hard for every candidate. Daily questions are among the habits toppers share most: in DrG's September 2026 tally of 27 topper interviews, 26 mentioned them, the same number as mentioned revision cycles.
PrepLadder's 90-day timetable groups Biochemistry with Pharmacology and Microbiology as high-volatility subjects to emphasise in the final days, and an older PrepLadder guide says to revise metabolic cycles close to the exam. Space your revisions instead of bunching them; one creator's September 2026 video on BTR (Dr Ritik Sharma) lays out a 1-3-4-7-21 spaced-revision schedule. Keep the last full pass inside the final month.
| Topic | What to know |
|---|---|
| Carbohydrate metabolism | Glycolysis and the TCA cycle with their regulated steps, glycolysis enzyme deficiencies, gluconeogenesis, the HMP shunt, glycogen storage disorders, fructose and galactose disorders. |
| Lysosomal storage diseases | Gaucher, Niemann-Pick, Tay-Sachs and Fabry: the deficient enzyme and the tell-tale sign or cell (Gaucher cells, cherry-red spot, angiokeratomas). |
| Urea cycle and amino acids | Urea-cycle disorders, amino-acid disorders, haemoglobin. |
| Molecular biology | Replication, transcription, translation, DNA repair, PCR, recombinant DNA and microarrays. |
| Enzymes | Km and Vmax as concepts, and the marker enzymes of cell organelles; leave long kinetics calculations alone. |
| Vitamins and nutrition | Deficiency diseases with their clinical picture, and minerals. Nutrition is a most-repeated PYQ area. |
| Haem metabolism | Porphyrias and the hyperbilirubinaemias. |
| Lipids | Fatty-acid synthesis and lipid metabolism, which PrepLadder's repeat list pairs with carbohydrates. |
| Membranes and receptors | Transport across membranes and receptors; cystic fibrosis is the classic membrane-transport (chloride-channel) defect. |
| Lab tests and structures | Benedict's and Fehling's tests, the electron transport chain, mucopolysaccharide and glycoprotein structures and the α-helix, all from PrepLadder's image set. |
Compiled from PrepLadder's 2026 high-yield, study-or-skip and most-repeated PYQ lists, its Biochemistry topic and image guides, and ReflexPrep.
Carbohydrates (glycolysis, TCA, gluconeogenesis, HMP shunt, glycogen disorders), then lipids. Redraw each pathway and mark its enzyme defects before solving the PYQs.
Urea cycle and amino-acid disorders, porphyrias and hyperbilirubinaemias, lysosomal storage diseases, and vitamin deficiencies with their clinical pictures.
Replication to translation, DNA repair, PCR and recombinant DNA, Km and Vmax, then the image set (structures, lab tests, clinical photos) and a timed PYQ set.
Why three days. PrepLadder's 90-day timetable gives Biochemistry three and Marrow's older 12-week plan two, which works as a revision pass once the subject has been studied properly. A first pass from scratch means main videos or textbook chapters one at a time, each followed by its Qbank. During clinical years and internship, keep Careers360's 20–30 minutes on most days and one short MCQ set a week.
Careers360 expects about 4–6 of the 180 and ReflexPrep 6–9 (August 2026), so roughly 4–9; both are recall-based. Other questions borrow from it too, because Biochemistry is often folded into multi-subject cases.
The most consistent recommendation is Dr Rebecca James (Marrow), credited by 2022 AIR 1 Dr Shagun Batra, and students also name Dr Rajesh Jambhulkar (PW MedEd). The rest of the 2026 line-up: Dr C Shanmugapriya (PrepLadder), Dr Ankur Jain and Dr Smily Pruthi (Cerebellum), Dr Amit Jain (DBMCI One) and Dr Priyansh Jain (DocTutorials).
Draw them, repeatedly, and attach a disease to every blocked step; that is Medioks' advice for 1st year and it holds for NEET PG. Then revise them close to the exam, since PrepLadder calls metabolic cycles volatile.
Yes, if you study it selectively, as PrepLadder's 2026 guide advises. The PYQ areas repeat, and its questions turn up inside Paediatrics, Pathology and Medicine cases. Give it a defined slot rather than the start of your preparation.
Rebuild it before final year with one platform's videos, main or rapid revision depending on how much you remember, plus its Qbank, then the PYQs topic by topic. It is not too late: Dr Soumyaditya reached his 1st- and 2nd-year subjects only in internship and went on to INI-CET AIR 2. The 1st-year guide has the first-year approach.
Black and white works for the text and most pathway charts. Print the clinical-photo pages and any colour-coded charts in colour, and bind Biochemistry as its own slim volume. Message the PDF on WhatsApp and we will send a quote.
Send your Biochemistry PDF on WhatsApp, whether it is a platform's rapid-revision notes, BTR or your own pathway sheets. We print the text in black and white with colour only where the pages need it, bind Biochemistry as a slim volume of its own and ship it to any address in India.
Order on WhatsAppTopper interviews, student resource videos and comments, PYQ and topic analyses, and 2025–26 exam reviews, read in October 2026.